Synthesis and immunostimulatory activity of substituted TLR7 agonists

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• 作者：Babatope Akinbobuyi^c ; Lei Wang^b ; Katherine C. Upchurch^a ; ^b ; Matthew R. Byrd^c ; Charles A. Chang^a ; Jeremy M. Quintana^c ; Rachel E. Petersen^c ; Zacharie J. Seifert^c ; José ; R. Boquin^d ; SangKon Oh^a ; ^b ; Robert R. Kane^a ; ^b ; ^c ; ^{bob_kane@baylor.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：OBUPDZRPERDFCP-UHFFFAOYSA-N ; JVVCWMDULJCEGQ-UHFFFAOYSA-N ; TXQLUFILKKFPPO-UHFFFAOYSA-N ; YINVDTUWROXJTQ-UHFFFAOYSA-N ; FUIPTEIGXVAOLP-UHFFFAOYSA-N ; ZEUXCBFSSBGNQZ-UHFFFAOYSA-N ; GSTVLAOHUWCQBG-UHFFFAOYSA-N ; TUDYTYZKPNPTRO-UHFFFAOYSA-N ; BSSHKITYSOTPES-UHFFFAOYSA-N ; SIZLIBXOAUTSRC-UHFFFAOYSA-N ; IJOGHMWKQQWGLD-UHFFFAOYSA-N ; GHUVYYMKWPPGCC-UHFFFAOYSA-N ; BPBXEBUYSVFBDI-UHFFFAOYSA-N ; PUHGNHDWUKJYKC-UHFFFAOYSA-N ; BPVAASZEZZXXNA-UHFFFAOYSA-N ; UCBAQQNXDUEVFP-UHFFFAOYSA-N ; XINUHWUOKMRTNJ-UHFFFAOYSA-N ; OPONHEK
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 September 2016
• 年：2016
• 卷：26
• 期：17
• 页码：4246-4249
• 全文大小：939 K

文摘

Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.