Therapeutic drug monitoring of immunosuppressants by liquid chromatography-mass spectrometry
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- 作者：Adam J. McShanea ; Dustin R. Buncha ; b ; Sihe Wanga ; b ; wangs2@ccf.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Therapeutic drug monitoring ; Immunosuppressant ; Liquid chromatography ; Mass spectrometry ; Cyclosporine A ; Tacrolimus ; Sirolimus ; Everolimus
- 刊名：Clinica Chimica Acta
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：454
- 期：Complete
- 页码：1-5
- 全文大小：429 K
文摘
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Immunoassays are prone to interferences.
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LC–MS/MS methods show greater accuracy due to its high specificity.
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Dried blood spot is a convenient specimen type for LC–MS/MS analysis.
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Commercialization of LC–MS/MS methods or calibrators improves standardization.
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New LC methods and extraction techniques can increase throughput.