Metabolomics: Perspectives on potential biomarkers in organ transplantation and immunosuppressant toxicity
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- 作者：E. Bonneaua ; N. Té ; treaultb ; R. Robitaillea ; A. Boucherc ; V. De Guirea ; vdeguire.hmr@ssss.gouv.qc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Metabolomics ; Biomarkers ; Metabolites ; Transplantation ; Diagnostic ; Immunosuppressants toxicity ; Rejection ; Toxicity ; NMR spectroscopy ; Mass spectrometry
- 刊名：Clinical Biochemistry
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：49
- 期：4-5
- 页码：377-384
- 全文大小：413 K
文摘
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The basics of metabolomics and analytical strategies used in the field are presented.
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Potential applications of metabolomics in organ transplantation including acute rejection diagnosis, immunosuppressant toxicity, ischemia/reperfusion injuries and delayed graft function are covered.
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Relevant metabolites in organ transplantation are summarized in Table 2.
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The most promising metabolites and limitations of metabolomics are discussed.