Investigations on the immunosuppressive activity of derivatives of mycophenolic acid in immature dendritic cells

详细信息    查看全文

• 作者：Dorota Iwaszkiewicz-Grzes^a ; ^b ; Grzegorz Cholewinski^a ; ^{grzchole@pg.gda.pl} ; Agata Kot-Wasik^c ; Piotr Trzonkowski^b ; Krystyna Dzierzbicka^a
• 关键词：Mycophenolic acid ; Amino acids ; Acridines ; Acridones ; Dendritic cells ; Immunosuppressants
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：137-142
• 全文大小：463 K
• 卷排序：44

文摘

Designed MPA derivatives inhibited the maturation of DC. Pro-inflammatory cytokines level was also reduced. Several compounds were more active towards IL-2 than parent MPA. Two acridone derivatives of MPA increased anti-inflammatory cytokines level.