The impact of pneumococcal conjugate vaccines on carriage of and disease caused by Streptococcus pneumoniae serotypes 6C and 6D in southern Israel
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- 作者：Nurith Porata ; b ; npurat@bgu.ac.il" class="auth_mail" title="E-mail the corresponding author ; Rachel Benistya ; b ; Noga Givon-Lavia ; b ; Ronit Treflera ; b ; Ron Dagana ; b
- 关键词：Streptococcus pneumoniae ; Serotype 6C ; Serotype 6D ; Pulsed field gel electrophoresis ; Multilocus sequence typing
- 刊名：Vaccine
- 出版年：2016
- 出版时间：27 May 2016
- 年：2016
- 卷：34
- 期：25
- 页码：2806-2812
- 全文大小：1192 K
文摘
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A prospective surveillance was conducted in children <5 years in southern Israel.
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We assessed the impact of PCV7/PCV13 sequential introduction on the dynamics of serotypes 6C/6D.
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PCV introduction resulted in decreased carriage rates and conjunctivitis caused by 6C/6D.
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Incidences of 6C/6D decreased in otitis media and dropped to zero in IPD in the PCV13 era.
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We conclude that 6C/6D do not act as replacement serotypes for 6A/6B following PCV13 vaccination.