Detection of diarrhetic shellfish poisoning toxins using high-sensitivity human cancer cell-based impedance biosensor
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- 作者：Ling Zoua ; 1Author Vitae ; Qin WangaAuthor Vitae ; Mengmeng TongbAuthor Vitae ; Hongbo LiaAuthor Vitae ; Jun WangaAuthor Vitae ; Ning Hua ; 1 ; huning@zju.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Ping Wanga ; cnpwang@zju.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Human cancer cell-based impedance biosensor ; Diarrhetic shellfish poisoning toxin ; Okadaic acid ; Toxin-induced cytotoxicity
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：222
- 期：Complete
- 页码：205-212
- 全文大小：2445 K
文摘
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We established two human cancer cell-based impedance biosensors (CIB) to detect DSP toxins in dynamic and real-time way.
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Comparative experiments in DSP toxins detection were carried out between CIB and conventional cell-based assay (CCK8).
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CIB method presents a good correlation with mouse bioassay (MBA) and LC–MS–MS in DSP toxins detection.