Effectiveness of blonanserin for patients with drug treatment-resistant schizophrenia and dopamine supersensitivity: A retrospective analysis

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• 作者：Masumi Tachibana^a ; ^b ; Tomihisa Niitsu^a ; ^{niitsu@chiba-u.jp} ; Motoki Watanabe^b ; Tasuku Hashimoto^a ; Nobuhisa Kanahara^c ; Masatomo Ishikawa^a ; Masaomi Iyo^a ; ^c
• 关键词：BPRS ; Brief Psychiatric Rating Scale ; CGI-S ; Clinical Global Impression-Severity of Illness ; CP ; chlorpromazine-equivalent doses of antipsychotics ; DRD2 ; dopamine D2 receptors ; DSP ; dopamine supersensitivity psychosis ; GAF ; Global Assessment of Functioning Scale ; TRS ; drug treatment-resistant schizophrenia
• 刊名：Asian Journal of Psychiatry
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：24
• 期：Complete
• 页码：28-32
• 全文大小：300 K
• 卷排序：24

文摘

Blonanserin improved schizophrenia/dopamine supersensitivity patients’ symptoms. Total BPRS and GAF scores were significantly improved by 3 months at the latest. BPRS positive symptoms and CGI-S scores were improved by 6 months at the latest. Total antipsychotic doses were reduced after 12 months of blonanserin treatment.