Highly selective solid phase extraction and preconcentration of Azathioprine with nano-sized imprinted polymer based on multivariate optimization and its trace determination in biological and pharmaceutical samples

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• 作者：Saied Saeed Hosseiny Davarani^a ; ^{ss-hosseiny@cc.sbu.ac.ir} ; ^{s_davarani@yahoo.com} ; Zeinab Rezayati zad^a ; Ali Reza Taheri^b ; Nasrin Rahmatian^b
• 关键词：Azathioprine ; Nano molecularly imprinted polymer ; Solid-phase extraction ; Spectrophotometry ; Box&ndash ; Behnken design
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：572-583
• 全文大小：1826 K
• 卷排序：71

文摘

The nanosized-imprinted polymer has been synthesized by precipitation polymerization technique. A molecularly imprinted solid-phase extraction procedure was performed for determination of Azathioprine. The Azathioprine-molecular imprinting polymer can be considered for quality control of pharmaceutical preparations. In order to investigate the effect of variables, the Box–Behnken Design (BBD) under Response Surface Methodology (RSM) was employed.