Structural basis of urea-induced unfolding: Unraveling the folding pathway of hemochromatosis factor E
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- 作者：Parvez Khan ; Amresh Prakash ; Md. Anzarul Haque ; Asimul Islam ; Md. Imtaiyaz Hassan ; mihassan@jmi.ac.in" class="auth_mail" title="E-mail the corresponding author ; imtiyaz.hassan@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Faizan Ahmad
- 关键词：Pre-molten globule ; Hemochromatosis ; Urea denaturation ; Protein stability ; Folding intermediate
- 刊名：International Journal of Biological Macromolecules
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：1051-1061
- 全文大小：3398 K
文摘
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We determined mechanism of urea-induced unfolding of HFE.
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Urea-induced unfolding of HFE is a biphasic and reversible process.
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Urea-induced unfolding of HFE goes through a pre-molten globule state.
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The intermediate state is characterized by ANS-binding.