Size-dependent studies of macromolecular crowding on the thermodynamic stability, structure and functional activity of proteins: in vitro and in silico approaches
刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:February 2017
年:2017
卷:1861
期:2
页码:178-197
全文大小:1040 K
卷排序:1861
文摘
First review on size–dependent studies of macromolecular crowding Internal architecture of macromolecular crowding plays a significant role. It affects stability, structure and functional activity of proteins. Volume exclusion due to interdependence of concentration and size of the crowder. Small sized crowders have been found to be more effective.