Immunogenicity and safety of high-dose trivalent inactivated influenza vaccine compared to standard-dose vaccine in children and young adults with cancer or HIV infection
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- 作者：Hana Hakima ; d ; Hana.Hakim@stjude.org" class="auth_mail" title="E-mail the corresponding author ; Kim J. Allisona ; Lee-Ann Van de Veldea ; Li Tangb ; Yilun Sunb ; Patricia M. Flynna ; c ; d ; Jonathan A. McCullersa ; c ; jmccullers@uthsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Influenza vaccine ; High dose ; Cancer ; HIV ; Immune response ; Safety
- 刊名：Vaccine
- 出版年：2016
- 出版时间：8 June 2016
- 年：2016
- 卷：34
- 期：27
- 页码：3141-3148
- 全文大小：1025 K
文摘
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High dose influenza vaccine was more immunogenic than standard dose influenza vaccine in children and young adults with leukemia or solid tumor, but not with HIV.
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High dose influenza vaccine was safe and well-tolerated in children and young adults with leukemia, solid tumor, or HIV.
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Two doses of influenza vaccine were more immunogenic than one dose, especially against H1 and B antigens, in children and young adults with leukemia or solid tumor, but not with HIV.