Adverse events following pandemic influenza A (H1N1) 2009 monovalent and seasonal influenza vaccinations during the 2009-2010 season in the active component U.S. military and civilians aged 17-44 years reported to the Vaccine Adverse Event Reporting System

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• 作者：Barbara H. Bardenheier ; PhD ; MPH ; MA^a ; Susan K. Duderstadt ; MD ; MPH^a ; Renata J.M. Engler ; MD^b ; Michael M. McNeil ; MD ; MPH^a ; ^{mmm2@cdc.gov" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Pandemic influenza A H1N1 (2009) influenza vaccine ; Vaccine safety
• 刊名：Vaccine
• 出版年：2016
• 出版时间：17 August 2016
• 年：2016
• 卷：34
• 期：37
• 页码：4406-4414
• 全文大小：619 K

文摘

No comparative review of Vaccine Adverse Event Reporting System (VAERS) submissions following pandemic influenza A (H1N1) 2009 and seasonal influenza vaccinations during the pandemic season among U.S. military personnel has been published.

Methods

We compared military vs. civilian adverse event reporting rates. Adverse events (AEs) following vaccination were identified from VAERS for adults aged 17–44 years after pandemic (monovalent influenza [MIV], and seasonal (trivalent inactivated influenza [IIV3], live attenuated influenza [LAIV3]) vaccines. Military vaccination coverage was provided by the Department of Defense’s Defense Medical Surveillance System. Civilian vaccination coverage was estimated using data from the National 2009 H1N1 Flu Survey and the Behavioral Risk Factor Surveillance System survey.

Results

Vaccination coverage was more than four times higher for MIV and more than twenty times higher for LAIV3 in the military than in the civilian population. The reporting rate of serious AE reports following MIV in service personnel (1.19 per 100,000) was about half that reported by the civilian population (2.45 per 100,000). Conversely, the rate of serious AE reports following LAIV3 among service personnel (1.32 per 100,000) was more than twice that of the civilian population. Although fewer military AEs following MIV were reported overall, the rate of Guillain–Barré Syndrome (GBS) (4.01 per million) was four times greater than that in the civilian population. (1.04 per million).

Conclusions

Despite higher vaccination coverage in service personnel, the rate of serious AEs following MIV was about half that in civilians. The rate of GBS reported following MIV was higher in the military.