An inactivated influenza D virus vaccine partially protects cattle from respiratory disease caused by homologous challenge

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• 作者：Ben M. Hause^a ; ^b ; ^{bhause@cambridgetechnologies.net} ; Lucas Huntimer^c ; Shollie Falkenberg^c ; ¹ ; Jamie Henningson^a ; ^b ; Kelly Lechtenberg^d ; Tom Halbur^c
• 关键词：Influenza ; Bovine ; Respiratory disease ; Vaccine ; Pathogenesis
• 刊名：Veterinary Microbiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：199
• 期：Complete
• 页码：47-53
• 全文大小：1219 K
• 卷排序：199

文摘

The emerging influenza D virus (IDV) caused respiratory disease in calves. A homologous inactivated vaccine was immunogenic and partially protective. IDV titers in vaccinated calves were significantly reduced compared to controls. Fewer vaccinates were positive for IDV by immunohistochemistry. These results demonstrate an etiologic role for IDV in bovine respiratory disease.