Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: A systematic review and meta-analysis

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• 作者：Alexander Domnich^a ; Lucia Arata^a ; Daniela Amicizia^a ; Joan Puig-Barberà ; ^b ; Roberto Gasparini^a ; Donatella Panatto^a ; ^{panatto@unige.it}
• 关键词：Influenza vaccine ; MF59-adjuvanted vaccine ; Elderly ; Influenza vaccine effectiveness ; Meta-analysis
• 刊名：Vaccine
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：35
• 期：4
• 页码：513-520
• 全文大小：389 K
• 卷排序：35

文摘

Traditional inactivated flu vaccines are often poorly immunogenic in the elderly. Adjuvantation with MF59 may increase vaccine effectiveness among seniors. The aim was to assess MF59-vaccine effectiveness in preventing influenza-related outcomes. Our review suggests that MF59-adjuvanted vaccine is highly effective in the elderly. Field effectiveness of MF59-adjuvanted vaccine is superior to unadjuvanted vaccines.