Prefrontal cortical GABAergic and NMDA glutamatergic regulation of delayed responding

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• 作者：Meagan L. Auger ; Stan B. Floresco ; ^{floresco@psych.ubc.ca}
• 关键词：Gamma-aminobutyric acid ; NMDA receptor ; Prefrontal cortex ; Working memory ; GluN2B ; Schizophrenia
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：10-20
• 全文大小：1377 K
• 卷排序：113

文摘

PFC inactivation or disinhibition induces delay-independent impairments in delayed-responding. Non-selective antagonism of PFC NMDA receptors impairs delayed responding in a more delay-dependent manner. PFC GluN2B subunit-containing NMDA receptors do not appear to mediate delayed-responding. PFC NMDA and GABA-A receptors may differentially regulate components of working memory in rodents. Deficiencies in PFC GABA and NMDA receptor signalling may both contribute to working memory impairments in schizophrenia.