Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme
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- 作者：André ; Otá ; vio Peres Protzeka ; Luiz Fernando Rezendea ; José ; Maria Costa-Jú ; niora ; Sandra Mara Ferreiraa ; Ana Paula Gameiro Cappellia ; Flá ; via Maria Moura de Paulaa ; Jane Cristina de Souzaa ; Mirian Ayumi Kurautia ; Everardo Magalhã ; es Carneiroa ; Alex Rafachob ; c ; 1 ; alex.rafacho@ufsc.br" class="auth_mail" title="E-mail the corresponding author ; Antonio Carlos Boscheroa ; 1 ; boschero@unicamp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：AI ; adrenal incidentaloma ; AD ; Alzheimeŕs disease ; AUC ; area-under-curve ; CTL ; saline-treated group ; CNTF ; ciliary neurotrophic factor ; GC ; glucocorticoid-treated group ; ipGTT ; intraperitoneal glucose tolerance test ; ipITT ; intraperitoneal insulin tolerance test ; IR ; insulin resistance ; KITT ; constant rate of glucose decay ; RIA ; radioimmunoassay ; T2DM ; type 2 diabetes mellitus
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：155
- 期：part_PA
- 页码：1-8
- 全文大小：1327 K
文摘
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Dexamethasone (DEX) in excess causes insulin insensitivity and hyperinsulinemia in rodents.
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DEX-induced hyperinsulinemia is associated to reduced insulin clearance in rats and mice.
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Reduced insulin clearance is associated to decreased activity of hepatic IDE, mainly in rats.
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Reduction in hepatic IDE activity results from post-translational modulation, at least in rats.
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Downregulation of insulin clearance may be beneficial for the glycemic control.