A photopolymerized composite hydrogel and surgical implanting tool for a nucleus pulposus replacement

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• 作者：Andreas Schmocker^a ; ^b ; ¹ ; Azadeh Khoushabi^a ; ^c ; ¹ ; Daniela A. Frauchiger^d ; Benjamin Gantenbein^d ; Constantin Schizas^e ; ² ; Christophe Moser^b ; Pierre-Etienne Bourban^c ; Dominique P. Pioletti^a ; ^{dominique.pioletti@epfl.ch" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Medical device ; poly(ethylene-glycol)dimethacrylate ; Minimally invasive surgery ; Nano-cellulose fibers ; Orthopedic implant ; Photopolymerization
• 刊名：Biomaterials
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：88
• 期：Complete
• 页码：110-119
• 全文大小：1709 K

文摘

Nucleus pulposus replacements have been subjected to highly controversial discussions over the last 40 years. Their use has not yet resulted in a positive outcome to treat herniated disc or degenerated disc disease. The main reason is that not a single implant or tissue replacement was able to withstand the loads within an intervertebral disc. Here, we report on the development of a photo-polymerizable poly(ethylene glycol)dimethacrylate nano-fibrillated cellulose composite hydrogel which was tuned according to native tissue properties. Using a customized minimally-invasive medical device to inject and photopolymerize the hydrogel insitu, samples were implanted through an incision of 1 mm into an intervertebral disc of a bovine organ model to evaluate their long-term performance. When implanted into the bovine disc model, the composite hydrogel implant was able to significantly re-establish disc height after surgery (p < 0.0025). The height was maintained after 0.5 million loading cycles (p < 0.025). The mechanical resistance of the novel composite hydrogel material combined with the minimally invasive implantation procedure into a bovine disc resulted in a promising functional orthopedic implant for the replacement of the nucleus pulposus.