Spectral and molecular modeling investigations of supramolecular complexes of mefenamic acid and aceclofenac with α- and β-cyclodextrin

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• 作者：S. Siva^a ; ^{sivas7686@yahoo.co.in} ; S. Kothai Nayaki^b ; N. Rajendiran^a
• 关键词：Mefenamic acid ; Aceclofenac ; Cyclodextrin ; Inclusion complex ; TEM ; Molecular modeling
• 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
• 出版年：2017
• 出版时间：5 March 2017
• 年：2017
• 卷：174
• 期：Complete
• 页码：349-362
• 全文大小：2250 K
• 卷排序：174

文摘

MFA and ALF drugs formed 1:1 inclusion complex with α-CD and β-CD at pH ∼ 1 and pH ∼ 7. Phenyl ring (COOH group substituted) is present in the hydrophilic part of the CD. Complex formation was confirmed by SEM, FTIR, 1H NMR, DSC and XRD methods. Nanostructures were observed from drug-CD complex in the presence of water by TEM. Hydrogen bonds play a major role in the inclusion process.