Use of a rat ex-vivo testis culture method to assess toxicity of select known male reproductive toxicants
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- 作者：Keith M. Goldsteina ; goldsteinkm@lilly.com" class="auth_mail" title="E-mail the corresponding author ; David E. Seylera ; Philippe Durandb ; Marie-Hé ; lè ; ne Perrardc ; Thomas K. Bakera
- 关键词：DNB ; 1 ; 3-dinitrobenzene ; MAA ; 2-methoxyacetic acid ; BPA ; bisphenol A ; BTB ; blood&ndash ; testis barrier ; 2-ME ; 2-methoxyethanol ; TEER ; trans-epithelial electrical resistance ; Cx43 ; connexin-43 ; Cldn11 ; claudin-11 ; SpG ; spermatogonia ; SpC ; spermatocyte ; RS ; round spermatocyte
- 刊名：Reproductive Toxicology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：60
- 期：Complete
- 页码：92-103
- 全文大小：1160 K
文摘
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An in vitro model of spermatogenesis was evaluated with four testicular toxicants.
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10">In vitro findings correlated with in vivo pathology and known mechanisms.
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15">DNB targeted both Sertoli and germ cells within 2 weeks.
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MAA and BPA targeted Sertoli cells and blocked meiotic progression of germ cells.
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Lindane targeted Sertoli cells and caused death of meiotic spermatocytes in vitro.