An in vitro model of spermatogenesis was evaluated with four testicular toxicants.
10">In vitro findings correlated with in vivo pathology and known mechanisms.
15">DNB targeted both Sertoli and germ cells within 2 weeks.
MAA and BPA targeted Sertoli cells and blocked meiotic progression of germ cells.
Lindane targeted Sertoli cells and caused death of meiotic spermatocytes in vitro.