Behavioural sensitisation to MK-801 is dose-dependent and independent of environmental context
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- 作者：Emilia M. Lefevrea ; Darryl W. Eylesa ; b ; Thomas H.J. Burnea ; b ; t.burne@uq.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sensitisation ; MK-801 ; NMDA receptor ; Environmental context ; Animal model ; Schizophrenia
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：298
- 期：part_PB
- 页码：241-245
- 全文大小：504 K
文摘
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Repeated exposure to the NMDA receptor antagonist MK-801 induced locomotor sensitisation in male Sprague Dawley rats.
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Sensitisation to MK-801 was dose-dependent.
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MK-801 induced sensitisation was not affected by the environmental context in which drug exposure occurred.