Structural Basis for the Activation of IKK1/α
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- 作者：Smarajit Polley1 ; 2 ; 3 ; Dario Oliveira Passos2 ; De-Bin Huang1 ; Maria Carmen Mulero1 ; Anup Mazumder1 ; Tapan Biswas1 ; Inder M. Verma2 ; Dmitry Lyumkis2 ; dlyumkis@salk.edu" class="auth_mail" title="E-mail the corresponding author ; Gourisankar Ghosh1 ; 4 ; gghosh@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：17
- 期：8
- 页码：1907-1914
- 全文大小：2909 K
文摘
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The X-ray and EM structures reveal that IKK1/α assembles as a trimer of dimers
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Mutation of the trimer-forming surface abrogates processing of NF-κB2/p100 into p52
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The trimer-forming surface is important for interaction with NIK