Salvage ablative therapy in prostate cancer: International multidisciplinary consensus on trial design
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- 作者：Willemien van den Bos ; M.D.<sup>asup><sup> ; sup><sup>w.vandenbos@amc.uva.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; Berrend G. Muller ; M.D.<sup>asup> ; Daniel M. de Bruin ; Ph.D.<sup>asup> ; Andre Luis de Castro Abreu ; M.D.<sup>bsup> ; Christian Chaussy ; M.D.<sup>csup> ; Jonathan A. Coleman ; M.D.<sup>dsup> ; Antonio Finelli ; M.D.<sup>esup> ; Inderbir S. Gill ; M.D.<sup>fsup> ; Mitchell E. Gross ; M.D.<sup>fsup> ; Sjoerd F.M. Jenniskens ; M.D. ; P.h.D.<sup>gsup> ; Frank Kahmann ; M.D.<sup>hsup> ; M. Pilar Laguna-Pes ; M.D. ; P.h.D.<sup>asup> ; Ardeshir R. Rastinehad ; M.D.<sup>isup> ; Lucy A. Simmons ; M.D.<sup>jsup> ; Tullio Sulser ; M.D.<sup>ksup> ; Arnauld Villers ; M.D. ; P.h.D.<sup>lsup> ; John F. Ward ; M.D.<sup>msup> ; Jean J.M.C.H. de la Rosette ; M.D. ; P.h.D.<sup>asup>
- 关键词：Salvage ablative therapy ; Trial design ; Consensus
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：33
- 期：11
- 页码：495.e1-495.e7
- 全文大小：299 K
文摘
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Patients with recurrent disease after radiation therapy are candidates for SAT trials.
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Primary objective: Assessment of efficacy by negative biopsy rate at 12 months.
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Secondary objectives: Assessment of safety-profile and quality of life.
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Exclusion criteria should include evidence of local or distant metastases.
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The optimal biopsy strategy is image-guided targeted biopsies.
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Follow-up includes multiparametric MRI, PSA, and quality of life, at least 5 years.