A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas
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- 作者：Alice Soragni1 ; Deanna M. Janzen2 ; Lisa M. Johnson1 ; Anne G. Lindgren2 ; Anh Thai-Quynh Nguyen1 ; 8 ; Ekaterina Tiourin2 ; Angela B. Soriaga1 ; Jing Lu3 ; Lin Jiang1 ; 9 ; Kym F. Faull4 ; Matteo Pellegrini3 ; Sanaz Memarzadeh2 ; 5 ; 6 ; 7 ; smemarzadeh@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author ; David S. Eisenberg1 ; 7 ; david@mbi.ucla.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：11 January 2016
- 年：2016
- 卷：29
- 期：1
- 页码：90-103
- 全文大小：6021 K
文摘
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We designed the peptide ReACp53 to halt aggregation of p53 in cells
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ReACp53 rescues p53 transcription of target genes and restores apoptosis
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In vivo ReACp53 halts progression and shrinks tumors bearing aggregation-prone p53
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p53 aggregation in cancer is a target for therapy with ReACp53 as a lead compound