Genetic markers for antimony resistant clinical isolates differentiation from Indian Kala-azar
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- 作者：Supriya Khanraa ; Nibedeeta Rani Sarrafa ; Shantanabha Dasb ; 1 ; Anjan Kumar Dasc ; Syamal Royb ; 2 ; Madhumita Mannaa ; madhumita.manna09@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Indian kala-azar ; Leishmania donovani ; L. tropica ; Drug resistance ; Single stranded conformation polymorphism ; Genetic markers
- 刊名：Acta Tropica
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：164
- 期：Complete
- 页码：177-184
- 全文大小：1168 K
文摘
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The disease Indian Kala-azar has been associated with resistance to antimonial drug, Sodium Stibo Gluconate (SSG).
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SSG resistant and sensitive clinical isolates of KA were collected, identified and analyzed.
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SSG resistant isolates could be differentiated from sensitive ones by SSCP of ITS1, ITS2 and L0114.
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This is the first report on putative genetic markers for SSG resistance.