Synthesis of polyhydroxylated pyrrolizidine and indolizidine compounds and their glycosidase inhibitory activities

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• 作者：Thunwadee Ritthiwigrom ; Robert J. Nash ; Stephen G. Pyne
• 刊名：Tetrahedron
• 出版年：2010
• 出版时间：27 November 2010
• 年：2010
• 卷：66
• 期：48
• 页码：9340-9347
• 全文大小：613 K

文摘

The synthesis of the natural product 3-epi-casuarine and two tricyclic ether bridged analogues, plus 7-deoxy-3,6-diepi-casuarine, 7-epi-australine, 1-epi-castanospermine and 1,6-diepi-castanospermine is described. The glycosidase inhibitory activities of these compounds, along with that of uniflorine A and other polyhydroxylated pyrrolizidines and indolizidines that we have published before, are reported.