Phosphatidic acid induces EHD3-containing membrane tubulation and is required for receptor recycling
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- 作者：Yuji Henmia ; b ; e ; Natsuko Oea ; Nozomu Konoc ; Tomohiko Taguchid ; Kohji Takeib ; Kenji Tanabea ; tanabe.kenji@twmu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：EHD3 ; Eps15 homology domain-containing protein 3 ; EE ; early endosome ; ERC ; endocytic recycling compartment ; PM ; plasma membrane ; DGK ; diacylglycerol kinase ; DAG ; diacylglycerol ; LPAAT ; lysophosphatidic acid acyltransferase ; LPA ; lysophosphatidic acid ; FIPI ; 5-fluoro-2-indolyl des-chlorohalopemide ; PLD ; phospholipase D ; PLA2 ; phospholipase A2 ; PE ; phosphatidylethanolamine ; PC ; phosphatidylethanolcholine ; PS ; phosphatidylserine ; PA ; phosphatidic acid ; PIs ; phosphoinositides ; PtdIns(3)P ; phosphatid
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：342
- 期：1
- 页码：1-10
- 全文大小：2540 K
文摘
- 5">
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5">EHD3 binds to phosphatidic acid through its helical domain.
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The interaction between EHD3 and phosphatidic acid induced liposomal tabulation.
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5">Inhibition of PA synthesis reduced EHD3-containing tubules and impaired trafficking from early endosomes.