Dissolution enhancement of indomethacin-chitosan hydrochloride composite particles produced using supercritical assisted atomization
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- 作者：Hsien-Tsung Wu ; stwu@mail.mcut.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Chih-Pei Yang ; Shih-Chang Huang
- 关键词：Supercritical assisted atomization ; Chitosan hydrochloride ; Indomethacin ; Composite particles ; Drug controlled release
- 刊名：Journal of the Taiwan Institute of Chemical Engineers
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：67
- 期：Complete
- 页码：98-105
- 全文大小：1617 K
文摘
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Composite particles formation for indomethacin-chitosan hydrochloride via an SAA.
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Effects of size and CH/IMC mass ratio on drug dissolution rate were investigated.
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SAA-treated IMC transformed from γ-form to the meta-stable α-form.
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High CH/IMC mass ratio and micronized size could enhance IMC dissolution rate.
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Enhanced permeability could be beneficial for the bioavailability of API.