The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca2 + signalling in steatotic hepatocytes
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- 作者：Eunü ; s S. Alia ; Jin Huaa ; Claire H. Wilsonb ; George A. Tallisc ; Fiona H. Zhoud ; Grigori Y. Rychkovd ; Greg J. Barritta ; greg.barritt@flinders.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：NAFLD ; non-alcoholic fatty liver disease ; NASH ; non-alcoholic steatohepatitis ; T2D ; type 2 diabetes ; [Ca2 ; +]cyt ; cytoplasmic free Ca2 ; + concentration ; PKC ; protein kinase C ; PKA ; protein kinase A ; ER ; endoplasmic reticulum ; SERCA ; sarco/endoplasmic reticulum (Ca2 ; + + ; Mg2 ; +)ATP-ase ; SOCE ; store-operated Ca2 ; + entry ; SOC ; store-operated Ca2 ; + channel ; STIM ; stromal interaction molecule ; [Ca2 ; +]ext ; extracellular free Ca2 ; + concentration ; DBHQ ; 2 ; 5-di-(t
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1863
- 期：9
- 页码：2135-2146
- 全文大小：1590 K
文摘
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Exendin-4 reverses lipid-induced inhibition of Ca2 + entry in steatotic liver cells.
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Mechanism involves GLP-1 receptors, cyclic AMP, PKA and rapid lipolysis.
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Activation of Ca2 + entry may provide a new strategy for liver lipid reduction.