Differential effects of inhibitors of the PI3K/mTOR pathway on the expansion and functionality of regulatory T cells
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- 作者：Charlotte M. Huijts ; c.huijts@vumc.nl" class="auth_mail" title="E-mail the corresponding author ; Saskia J. Santegoets ; Maria Quiles del Rey ; Richard R. de Haas ; Henk M. Verheul ; Tanja D. de Gruijl ; Hans J. van der Vliet ; jj.vandervliet@vumc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：iTregs ; in vitro-induced Tregs ; LAP ; Latency Associated Peptide ; PD-1 ; programmed death-1 ; pNET ; pancreatic neuroendocrine tumor ; PTEN ; phosphatase and tensin homolog deleted on chromosome 10 ; pTregs ; peripherally derived Tregs ; Tconv ; conventional T cells ; Tregs ; CD4+ ; CD25hiFOXP3+ regulatory T cells ; tTregs ; thymus derived Tregs
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：168
- 期：Complete
- 页码：47-54
- 全文大小：1036 K
文摘
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Single mTOR and dual PI3K/mTOR inhibitors support a relative Treg expansion benefit.
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Single mTOR and dual PI3K/mTOR inhibitors promote Treg immunosuppressive activity.
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Single PI3K inhibition results in similar expansion rates of Tregs and Tconv.
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The suppressive activity of Tregs is not altered upon culture with PI3K inhibitors.