Networks of Cultured iPSC-Derived Neurons Reveal the Human Synaptic Activity-Regulated Adaptive Gene Program

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• 作者：Priit Pruunsild¹ ; C. Peter Bengtson¹ ; Hilmar Bading¹ ; ² ; ^{bading@nbio.uni-heidelberg.de}
• 关键词：human neurons ; neuronal networks ; NMDA receptor ; calcium signaling ; transcription ; genome-wide ; species specificity ; human adaptogenomics ; HIC1
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：122-135
• 全文大小：4130 K
• 卷排序：18

文摘

The repertoire of human activity-induced genes is expanded lineage specifically Temporal expression profiles of many activity-responsive genes are species specific Some human orthologs of mouse genes have gained inducibility by synaptic activity The human HIC1 gene promoter has gained an activity-responsive regulatory element