Neurobehavioral alterations plus transcriptional changes of the heat shock protein 90 and hypoxia inducible factor-1α in the crucian carp exposed to copper
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- 作者：Merylin Zizza ; Marcello Canonaco ; Rosa Maria Facciolo ; rm.facciolo@unical.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid ; ACS ; amino cupric silver stain ; Cu ; copper ; DIG ; digoxigenin-11-dUTP ; Dl ; lateral part of the dorsal telencephalon ; Dm ; medial part of the dorsal telencephalon ; HIF-1α ; hypoxia inducible factor-1alpha ; Hsp90 ; heat shock protein 90 ; NDLI ; diffuse nucleus of the inferior lobe ; NPGm ; medial preglomerular nucleus ; OD ; optical density ; OT ; optic tectum ; TLo ; torus longitudinalis ; VCe ; valvula of the cerebellum ; Vl ; lateral part of the ventr
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：52
- 期：Complete
- 页码：162-175
- 全文大小：3495 K
文摘
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CuCl2 exposure reduced swimming speed and food intake in the crucian carp.
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Scototaxis test pointed to an anxiety-like behavior in fish exposed to CuCl2.
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CuCl2 exposure accounted for Hsp90 and HIF-1α transcript variations in fish brain.
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Motor activities and food intake were rescued after recovery from 0.30 mg/L CuCl2.
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Behavioral and Hsp90/HIF-1α recoveries coincided with reduced neurodegeneration.