刊名:The International Journal of Biochemistry & Cell Biology
出版年:2017
出版时间:January 2017
年:2017
卷:82
期:Complete
页码:28-40
全文大小:5023 K
卷排序:82
文摘
Invasiveness of CoCl2 or 1% O2-treated gastric cancer cell (GCC) is reduced by CTK7A. CTK7A-mediated Noxa induction in CoCl2 and hypoxia-exposed GCC is Hif1-independent. CTK7A activates p38 MAPK by H2O2 generation and induces Noxa in hypoxia-exposed GCC. CTK7A induces Noxa-mediated apoptosis in hypoxia-exposed GCC.