Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance

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• 作者：Marina T. DiStefano¹ ; ⁴ ; Rachel J. Roth Flach¹ ; ⁵ ; Ozlem Senol-Cosar¹ ; ⁶ ; Laura V. Danai¹ ; ⁷ ; Joseph V. Virbasius¹ ; Sarah M. Nicoloro¹ ; Juerg Straubhaar¹ ; Sezin Dagdeviren² ; Martin Wabitsch³ ; Olga T. Gupta¹ ; ⁸ ; Jason K. Kim² ; Michael P. Czech¹ ; ^{Michael.Czech@umassmed.edu}
• 关键词：Obesity ; Adipocyte ; Lipid droplet ; Lipolysis ; Hypoxia-inducible gene 2 (Hig2)
• 刊名：Molecular Metabolism
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：5
• 期：12
• 页码：1149-1161
• 全文大小：2958 K
• 卷排序：5

文摘

Hig2 localizes to lipid droplets in adipocytes and promotes adipose tissue lipid deposition. Its selective deficiency in active brown/beige adipose tissue mediates improved glucose tolerance at 23 °C. Metabolic improvements are independent of changes in lipolysis.