Enhanced aggressiveness of bystander cells in an anti-tumor photodynamic therapy model: Role of nitric oxide produced by targeted cells

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• 作者：Jerzy Bazak^a ; Jonathan M. Fahey^b ; Katarzyna Wawak^a ; Witold Korytowski^a ; ^b ; ^{witekkor@mcw.edu} ; Albert W. Girotti^b ; ^{agirotti@mcw.edu}
• 关键词：Bystander effects ; Photodynamic therapy ; Nitric oxide ; Inducible NO synthase
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：111-121
• 全文大小：1256 K
• 卷排序：102

文摘

Prostate cancer PC3 cells overexpress iNOS/NO after PDT-like photodynamic targeting. NO from targeted cells diffuses to non-targeted bystander cells. Bystanders exhibit faster NO-dependent growth and migration than controls. Bystander responses reflect a feed-forward NO field effect. This is the first reported example of bystander NO signaling in the context of PDT.