Cardenolides from the Apocynaceae family and their anticancer activity

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• 作者：Shiyuan Wen^a ; ^b ; Yanyan Chen^a ; ^b ; Yunfang Lu^a ; ^b ; Yuefei Wang^a ; Liqin Ding^a ; Miaomiao Jiang^a ; ^{miaomiaojiang@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：TCM ; traditional Chinese medicine ; ODS column ; Octadecylsilyl ; RP-HPLC ; reverse phase high-performance liquid chromatography ; NMR ; Nuclear Magnetic Resonance ; NF-κB ; Nuclear Factor-kappaB ; JNK ; c-Jun NH2-terminal kinase ; AP-1 ; Activator Protein-1 ; ROS ; reactive oxygen species ; FGF-2 ; Fibroblast Growth Factor 2 ; IL-8 ; Interleukin-8 ; HIF1α ; hypoxia-inducible factor 1α ; MAPK ; mitogen-activate dprotein kinase ; ERK1/2 ; extracellular signal-regulated kinase 1/2 ; mTOR ; mammalian target of rapamycin
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：112
• 期：Complete
• 页码：74-84
• 全文大小：1371 K

文摘

Cardenolides, as a group of natural products that can bind to Na⁺/K⁺-ATPase with an inhibiting activity, are traditionally used to treat congestive heart failure. Recent studies have demonstrated that the strong tumor cytotoxicities of cardenolides are mainly due to inducing the tumor cells apoptosis through different expression and cellular location of Na⁺/K⁺-ATPase α-subunits. The leaves, flesh, seeds and juices of numerous plants from the genera of Nerium, Thevetia, Cerbera, Apocynum and Strophanthus in Apocynaceae family, are the major sources of natural cardenolides. So far, 109 cardenolides have been isolated and identified from this family, and about a quarter of them are reported to exhibit the capability to regulate cancer cell survival and death through multiple signaling pathways. In this review, we compile the phytochemical characteristics and anticancer activity of the cardenolides from this family.