Infectious salmon anemia virus segment 7 ORF1 and segment 8 ORF2 proteins inhibit IRF mediated activation of the Atlantic salmon IFNa1 promoter
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- 作者：Chun Li ; Linn Greiner-Tollersrud ; Bø ; rre Robertsen ; borre.robertsen@uit.no" class="auth_mail" title="E-mail the corresponding author
- 关键词：Interferon ; IFN ; IRF ; Promoter ; IPS-1 ; MAVS ; Infectious salmon anemia virus ; ISAV ; Antagonism ; Atlantic salmon ; Fish
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：52
- 期：Complete
- 页码：258-262
- 全文大小：682 K
文摘
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ISAV proteins s7ORF1 inhibited IRF3 and IRF7B induced IFNa1 promoter activity.
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ISAV protein s8ORF2 inhibited IRF1 and IRF3 induced IFNa1 promoter activity.
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Immunoprecipitation data suggest that s7ORF1 and s8ORF2 can bind to IRF1, IRF3, IRF7A or IRF7B.
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s7ORF1 and s8ORF2 did not inhibit activation of the IFNa1 promoter by the IFN promoter stimulating protein IPS-1.