ISAV proteins s7ORF1 inhibited IRF3 and IRF7B induced IFNa1 promoter activity.
ISAV protein s8ORF2 inhibited IRF1 and IRF3 induced IFNa1 promoter activity.
Immunoprecipitation data suggest that s7ORF1 and s8ORF2 can bind to IRF1, IRF3, IRF7A or IRF7B.
s7ORF1 and s8ORF2 did not inhibit activation of the IFNa1 promoter by the IFN promoter stimulating protein IPS-1.