IFN-adjuvanted DNA vaccine against infectious salmon anemia virus: Antibody kinetics and longevity of IFN expression
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- 作者：Bø ; rre Robertsen ; borre.robertsen@uit.no" class="auth_mail" title="E-mail the corresponding author ; Chia-Jung Chang ; Lisa Bratland
- 关键词：Adjuvant ; Antibody ; Atlantic salmon ; DNA vaccine ; Fish ; Hemagglutinin-esterase ; Interferon ; Infectious salmon anemia virus ; ISG15 ; Mx
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：328-332
- 全文大小：564 K
文摘
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IFN plasmids increased the antibody response induced by the ISAV hemagglutinin-esterase (HE) plasmid through week 22.
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The anti-ISAV antibody kinetics was different using IFNa- and IFNc plasmids as adjuvants.
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Fish injected with IFNc-plasmid alone showed systemic expression of Mx and ISG15 during 22 weeks.
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Vaccination with IFNc- and HE-plasmids together abolished systemic expression of Mx and ISG15 after 16–22 weeks.
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This suggests that the adaptive immune response against HE causes elimination of cells expressing HE.