• 作者：Almudena Gó ; mez-Herná ; ndez^a ; ^b ; ^c ; ^{almudenagomez@farm.ucm.es} ; Liliana Perdomo^a ; ^b ; ^c ; Ó ; scar Escribano^a ; ^b ; ^c ; Manuel Benito^a ; ^b ; ^c
• 关键词：Obesidad ; Tejido adiposo blanco ; Complicaciones vasculares
• 刊名：Cl¨ªnica e Investigaci¨®n en Arteriosclerosis
• 出版年：2013
• 出版时间：January-March, 2013
• 年：2013
• 卷：25
• 期：1
• 页码：27-35
• 全文大小：929 K

The contribution of white adipose tissue to the vascular complications associated with obesity is analysed in this review. White adipose tissue is an active metabolic organ and secretor of several molecules with endocrine, paracrine and autocrine actions. Weight gain produced in the obesity, induces an excess of fat, mainly in the visceral depot, which is responsible for the activation of different signalling pathways, leading to a higher production of proinflammatory cytokines. As adipocytes as infiltrated macrophages and lymphocytes and endothelial cells contribute to a chronic low grade inflammatory situation present in obesity. Moreover, the increase in adiposity activates the inflammatory response in the adipocyte themselves, as well as in the hepatocyte. Finally, proinflammatory and proatherogenic mediators produced by white adipose tissue and liver associated to immune cells generate insulin resistance in peripheral tissues and contribute to the beginning of atherogenic process.