Asiatic acid-pectin hydrogel matrix patch transdermal delivery system influences parasitaemia suppression and inflammation reduction in P. berghei murine malaria infected Sprague-Dawley rats

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• 作者：Greanious Alfred Alfrd Mavondo¹ ; ² ; ^{213574054@stu.ukzn.ac.za} ; ^{greaniousa@gmail.com} ; Musabayane Cephas Tagumirwa³
• 关键词：Asiatic acid ; Malaria parasitaemia ; Plasmodium berghei ; Transdermal delivery system ; Patch ; Malaria inflammation
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：12
• 页码：1172-1180
• 全文大小：1388 K
• 卷排序：9

文摘

To report the influence of transdermal delivery of asiatic acid (AA) in Plasmodium berghei-infected Sprague Dawley rats on physicochemical changes, %parasitaemia and associated pathophysiology.MethodsA topical once-off AA (5, 10, and 20 mg/kg)- or chloroquine (CHQ)-pectin patch was applied on the shaven dorsal neck region of Plasmodium berghei-infected Sprague Dawley rats (90–120 g) on day 7 after infection. Eating and drinking habits, weight changes, malaria effects and %parasitaemia were compared among animal groups over 21 d.ResultsAA-pectin patch application preserved food and water intake together with %weight gain. All animals developed stable parasitaemia (15–20%) by day 7. AA doses suppressed parasitaemia significantly. AA 5 mg/kg patch was most effective. AA and CHQ displayed bimodal time-spaced peaks. CHQ patch had a longer time course to clear parasitaemia.ConclusionsAA influences bio-physicochemical changes and parasitaemia suppression in dose dependent manner. In comparison by dose administered, AA has much better efficacy than CHQ. AA may be a useful antimalarial. AA and CHQ displays bimodal peaks suggesting possible synergism if used in combination therapy.