Protective effect of β-glucan against systemic Streptococcus pneumoniae infection in mice

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• 作者：Hetland ; Geir ; Ohno ; Naohito ; Aaberge ; Ingeborg S. ; L&oslash ; vik ; Martinus
• 关键词：β ; -1 ; 3-D-Glucan ; Antimicrobial effect ; Streptococcus pneumoniae
• 刊名：FEMS Immunology and Medical Microbiology
• 出版年：2000
• 出版时间：February, 2000
• 年：2000
• 卷：27
• 期：2
• 页码：111-116
• 全文大小：249 K

文摘

The antimicrobial effect of soluble β-1,3-D-glucan from Sclerotinia sclerotiorum (SSG) was examined in mice experimentally infected intraperitoneally (i.p.) with Streptococcus pneumoniae serotypes 4 and 6B. SSG was administered i.p. either 3 days before challenge or 3–48 h after challenge. The number of bacteria in blood samples and the mouse survival rates were recorded. Pre-challenge SSG administration protected dose-dependently against both S. pneumoniae type 4 and 6B infections. SSG injected 24 h post-challenge had a curative effect against type 6B but not type 4 pneumococcal infection. The data demonstrate that SSG administered systemically protects against pneumococcal infection in mice.