Selenoureido-iminosugars: A new family of multitarget drugs
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- 作者：Jacob Ingemar Olsena ; b ; Gabriela B. Platac ; José ; M. Padró ; nc ; Ó ; scar Ló ; pezb ; osc-lopez@us.es" class="auth_mail" title="E-mail the corresponding author ; Mikael Bolsa ; José ; G. Ferná ; ndez-Bolañ ; osb
- 关键词：Glycosidase inhibition ; Iminosugars ; Selenoureas ; AChE inhibition ; Antioxidant ; GPx mimic
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：10 November 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：155-160
- 全文大小：534 K
文摘
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Selenoureido deoxynojirimycin derivatives are attractive multitarget drugs.
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Iminosugars 6a–c are strong and selective β-glucosidase inhibitors (Ki = 1.6–5.5 μM).
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Derivative 6a strongly inhibits AChE (mixed, Kia = 5.8 μM, Kib = 11.2 μM).
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Derivative 6b is an excellent GPx mimic for scavenging H2O2 (Kcat/Kuncat = 640).