Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats
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- 作者：Inci Kazkayasia ; inci.kazkayasi@hacettepe.edu.tr" class="auth_mail" title="E-mail the corresponding author ; incikazkayasi@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Muhammad-Al-Mustafa Ismailb ; Cristina Parrado-Fernandezb ; Ingemar Bjö ; rkhemc ; Can Pekinera ; Serdar Umaa ; Angel Cedazo-Minguezb ; Nihan Burul-Bozkurta ; 1
- 关键词：Seladin-1 ; Insulin ; Alzheimer&rsquo ; s disease ; Diabetes mellitus ; BACE-1
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：28 October 2016
- 年：2016
- 卷：633
- 期：Complete
- 页码：174-181
- 全文大小：2073 K
文摘
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Growing evidence shows that diabetes enhances the risk for Alzheimer’s disease.
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Insulin deprivation decreased seladin-1 expression.
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Insulin deprivation increased BACE-1 expression.
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STZ-induced diabetes decreased seladin-1 but not BACE-1 expression in rat cortex.
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Insulin may act as a regulator of seladin-1 expression.