The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15
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- 作者：Rebecca B. Delconte1 ; 2 ; Wei Shi1 ; 2 ; 3 ; Priyanka Sathe1 ; 2 ; Takashi Ushiki1 ; 2 ; Cyril Seillet1 ; 2 ; Martina Minnich4 ; Tatiana B. Kolesnik1 ; 2 ; Lucille C. Rankin1 ; 2 ; Lisa A. Mielke1 ; 2 ; Jian-Guo Zhang1 ; 2 ; Meinrad Busslinger4 ; Mark J. Smyth5 ; 6 ; Dana S. Hutchinson7 ; Stephen L. Nutt1 ; 2 ; Sandra E. Nicholson1 ; 2 ; Warren S. Alexander1 ; 2 ; Lynn M. Corcoran1 ; 2 ; Eric Vivier8 ; 9 ; Gabrielle T. Belz1 ; 10 ; belz@wehi.edu.au" class="auth_mail" title="E-mail the corresponding author ; Sebastian Carotta1 ; 10 ; 11 ; Nicholas D. Huntington1 ; 10 ; huntington@wehi.edu.au" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：19 January 2016
- 年：2016
- 卷：44
- 期：1
- 页码：103-115
- 全文大小：3853 K
文摘
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Id2 is upregulated during NK cell maturation to titrate E-protein activity
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Id2 deletion in mature NK cells results in apoptosis
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Id2 suppresses SOCS3 expression to maintain IL-15 receptor signaling
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Requirement for Id2 is overcome by strong IL-15 receptor stimulation