LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization
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- 作者：Alexander Grotea ; alexander.grote@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Barbara K. Robensb ; 1 ; Ingmar Blü ; mckec ; Albert J. Beckerb ; Susanne Schochb ; d ; susanne.schoch@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Eva Gembé ; b ; 1
- 关键词：Malformation ; Migration ; In utero electroporation ; Differentiation ; Epilepsy
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：170-176
- 全文大小：1098 K
文摘
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Lipoprotein receptor-related protein 12 (LRP12) is critical for neurodevelopment.
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LRP12 knock-down impairs process formation of primary neurons.
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In vivo LRP12 knock-down in neuronal precursors results in cortical dyslamination.
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Increased seizure susceptibility in in utero electroporated LRP12 knock-down mice