Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain
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- 作者：Bunzel ; Roland ; Blü ; mcke ; Ingmar ; Cichon ; Sven ; Normann ; Sabine ; Schramm ; Johannes ; Propping ; Peter ; et. al.
- 关键词：Genomic imprinting ; HTR2A gene ; Monoallelic expression ; Neurobehavioral disorder ; Pharmacogenetic
- 刊名：Molecular Brain Research
- 出版年：1998
- 出版时间：August 15, 1998
- 年：1998
- 卷：59
- 期：1
- 页码：90-92
- 全文大小：114 K
文摘
We have examined the imprinting status of the serotonin-2A (5-HT2A) receptor gene (HTR2A) in a series of 41 tissue samples from human adult brain. Using a HpaII RFLP polymorphism in the coding region, we obtained evidence of monoallelic expression of HTR2A in 4 out of 18 informative individuals. However, biallelic expression of HTR2A was observed in other individuals (14/18), suggesting that within the human population HTR2A imprinting in brain is polymorphic.