Murine gammaherpesvirus targets type I IFN receptor but not type III IFN receptor early in infection
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- 作者：Katarí ; na Lopu&scaron ; ná ; a ; Tí ; mea Benkó ; czkaa ; Jakub Luptá ; kb ; Radka Matú ; &scaron ; ková ; a ; Ľubomí ; ra Luká ; čiková ; a ; Ingrid Ovečková ; a ; Ingeborg Režuchová ; a ; viruorav@savba.sk" class="auth_mail" title="E-mail the corresponding author
- 关键词：EBV ; Epstein-Barr virus ; FBS ; fetal bovine serum ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; HHV-4 ; human herpesvirus 4 ; HHV-8 ; human herpesvirus 8 ; hpi ; hours post infection ; IFN ; interferon ; IFNAR ; interferon α/β receptor ; IFN-λR ; interferon lambda receptor ; IRF-3 ; interferon regulatory factor 3 ; IRF-7 ; interferon regulatory factor-7 ; ISG ; interferon-stimulated gene ; Jak/STAT ; Janus kinase/signal transducers and activators of transcription ; KSHV ; Kaposi&rsquo ; s sarcoma-associated herpesv
- 刊名：Cytokine
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：158-170
- 全文大小：1702 K
文摘
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MuHV-4 manipulates the IFNs signaling network in a strain-dependent manner.
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MuHV-4 degrades type I but not type III IFN receptor in early stages of infection.
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Type III IFNs are important for epithelial cells defense in early MuHV-4 infection.
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IFN-β is the predominant type I IFN in NMuMG cells.
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NMuMG cells are an appropriate in vitro model to study IFN-I and IFN-III signaling.