Progressive Loss of Function in a Limb Enhancer during Snake Evolution
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- 作者：Evgeny Z. Kvon1 ; Olga K. Kamneva2 ; Uirá ; S. Melo1 ; Iros Barozzi1 ; Marco Osterwalder1 ; Brandon J. Mannion1 ; Virginie Tissiè ; res3 ; Catherine S. Pickle1 ; Ingrid Plajzer-Frick1 ; Elizabeth A. Lee1 ; Momoe Kato1 ; Tyler H. Garvin1 ; Jennifer A. Akiyama1 ; Veena Afzal1 ; Javier Lopez-Rios3 ; Edward M. Rubin1 ; 4 ; Diane E. Dickel1 ; Len A. Pennacchio1 ; 4 ; lapennacchio@lbl.gov" class="auth_mail" title="E-mail the corresponding author ; Axel Visel1 ; 4 ; 5 ; 6 ; avisel@lbl.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：cis-regulatory element ; enhancer ; limb development ; morphological evolution ; snakes ; CRISPR/Cas9 ; ZRS ; evo-devo ; Sonic hedgehog (Shh) ; genome editing
- 刊名：Cell
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：167
- 期：3
- 页码：633-642.e11
- 全文大小：4016 K
文摘
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Activity of the critical ZRS limb enhancer is highly conserved across vertebrates
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ZRS enhancer has progressively lost its function during snake evolution
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Snake-specific nucleotide changes contributed to the loss of ZRS enhancer function
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Resurrection of snake enhancer function in vivo