Protein kinase C isoenzyme: selective expression pattern of protein kinase C-θ during mouse development
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- 作者：Wilda ; Monika ; Ghaffari-Tabrizi ; Nassim ; Reisert ; Ingrid ; Utermann ; Gerd ; Baier ; Gottfried ; et. al.
- 关键词：Protein kinase C-θ ; RNA in situ hybridization ; Hematopoiesis ; Lymphopoiesis ; Yolk sac ; Liver ; Thymus ; Spleen ; Afferent neuronal conduction ; Dorsal root ganglia ; Trigeminal and facial ganglia ; Alar plate ; Gracile and cuneate fasciculi ; Medial lemniscu
- 刊名：Mechanisms of Development
- 出版年：2001
- 出版时间：May, 2001
- 年：2001
- 卷：103
- 期：1-2
- 页码：197-200
- 全文大小：1.13 M
文摘
Protein kinase C (PKC)-θ, a serine/threonine protein kinase and novel PKC subfamily member, has been recently identified as an essential component of the T cell synapse which activates the NF-kB signaling cascade leading to expression of the IL-2 gene during T cell activation. By RNA in situ hybridization to whole-body embryo sections it is shown that the murine PKCθ is specifically expressed in tissues with hematopoietic and lymphopoietic activity. Expression is also evident in skeletal muscle. A further highly specific expression was observed in the peripheral and central nervous system which is described in detail. Expression in the brain persists up to adult stages.