Transcription of the Y chromosomal gene, Sry, in adult mouse brain
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- 作者：Lahr ; Georgia ; Maxson ; Stephen C. ; Mayer ; Anette ; Just ; Walter ; Pilgrim ; Christof ; Reisert ; Ingrid
- 关键词：Sry ; Y chromosome ; Sexual dimorphism ; Mammal ; Hypothalamus ; Midbrain
- 刊名：Molecular Brain Research
- 出版年：1995
- 出版时间：October, 1995
- 年：1995
- 卷：33
- 期：1
- 页码：179-182
- 全文大小：286 K
文摘
The Y chromosomal gene Sry encodes a putative transcription factor which appears to serve as a master switch initiating testicular development. Here we show that this gene is transcribed in hypothalamus, midbrain, and testis of adult male but not adult female mice. In contrast to its circular transcripts in adult testis, those in brain are linear and may be translated. We propose that Sry exerts a role in the regulation of sex differentiation of the mammalian nervous system.