Hyperhomocysteinemia in Chronic Renal Failure: Alternative Therapeutic Strategies

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• 作者：Alessandra F. Perna ; MD ; PhD^&lowast ; ; ^{alessandra.perna@unina2.it} ; Immacolata Sepe ; PhD^&lowast ; ; Diana Lanza ; PhD^&lowast ; ; Rosa Maria Pollastro ; MD ; PhD^&lowast ; ; Natale G. De Santo ; MD^&lowast ; ; Diego Ingrosso ; MD ; PhD^&dagger ;
• 刊名：Journal of Renal Nutrition
• 出版年：2012
• 出版时间：January, 2012
• 年：2012
• 卷：22
• 期：1
• 页码：191-194
• 全文大小：113 K

文摘

Chronic renal failure and uremia represent states wherein high blood levels of homocysteine, a cardiovascular risk factor, are largely resistant to folate therapy. Indeed, normalization of homocysteine levels through vitamin administration is rarely achieved in this population, and this fact could explain, among other causes, the negative results of intervention trials designed to lower cardiovascular risk. Dialysis itself lowers homocysteine levels, albeit transitorily. N-acetylcysteine therapy could induce an additional decrease in homocysteine removal during dialysis, thus representing an alternative approach in the attempt to lower cardiovascular risk in these patients.